Molecular diagnosis of lymphoblastic leukemia
نویسندگان
چکیده
منابع مشابه
Leukemia Cutis in a Child with Acute Lymphoblastic Leukemia at Diagnosis and Relapse
این مقاله فاقد چکیده میباشد.
متن کاملDiagnosis and Subclassification of Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL) is a disseminated malignancy of B- or T-lymphoblasts which imposes a rapid and accurate diagnostic process to support an optimal risk-oriented therapy and thus increase the curability rate. The need for a precise diagnostic algorithm is underlined by the awareness that both ALL therapy and related success rates may vary greatly between ALL subsets, from standa...
متن کاملMolecular genetics of acute lymphoblastic leukemia.
From its beginnings two decades ago with the analysis of chromosomal translocation breakpoints, research into the molecular pathogenesis of acute lymphoblastic leukemia (ALL) has now progressed to the large-scale resequencing of candidate oncogenes and tumor suppressor genes in the genomes of ALL cases blocked at various developmental stages within the B- and T-cell lineages. In this review, we...
متن کاملMolecular pathogenesis of childhood acute lymphoblastic leukemia.
This concise review focuses on the most recent advances in understanding molecular genetic abnormalities in childhood acute leukemia (ALL). An increasing number of chromosomal translocations associated to distinct molecular genetic abnormalities have been described. Recurrent motifs have been recognized behind the great heterogeneity of genes involved in chromosomal translocations occurring in ...
متن کاملDiagnosis of intrachromosomal amplification of chromosome 21 (iAMP21) by molecular cytogenetics in pediatric acute lymphoblastic leukemia
Intrachromosomal amplification of chromosome 21 (iAMP21) defines a distinct cytogenetic subgroup of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with poor prognosis that should be investigated in routine practice. Single-nucleotide polymorphism (SNP)-array provides a useful method to detect such cases showing a highly characteristic profile.
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ژورنال
عنوان ژورنال: Journal of Cancer Research and Therapeutics
سال: 2013
ISSN: 0973-1482
DOI: 10.4103/0973-1482.119309